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Garry ShandlingHarold Anderson
Annette BeningSusan Anderson
John GoodmanRoland Jones
Greg KinnearPerry Gordon
Ben KingsleyGraydon
Judy GreerRebecca
Danny ZornRandy
Harmony SmithRita
Richard JenkinsDon Fisk
Linda FiorentinoHelen Gordon
Caroline AaronNadine Jones
Janeane GarofaloNervous Woman
Octavia SpencerBaby Nurse
Nora DunnMadeline- Cricky LongJanice
Camryn ManheimAlison
Ann CusackLiz
Jane LynchDoreen- Richard MinchenbergDr. Weitzman
Drinda LalumiaDrunken Lady
J.C. MacKenzieJohn
Willie GarsonBrett- Marjorie LovettNeighbor Woman
- Bil DwyerHusband
- Alexander LyrasMale AA
Stacey TravisWoman
Brian TeeAlien (sem créditos)
Sarah SilvermanWoman on plane
Phill LewisOther MD
Rick AveryAirlane Passenger (sem créditos)- Tori BridgesAirport Clerk (sem créditos)
James HunterAlien Student (sem créditos)