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Martin LawrenceMalcolm Turner / Big Momma
Marisol NicholsLiliana Morales
Kevin DurandOshima
Dan LauriaCrawford
Kat DenningsMolly Fuller
Josh FlitterStewart
Zachary LeviKevin Keneally
Jascha WashingtonTrent
Jeanene FoxYasmeen
Mark MosesTom Fuller
Chloë Grace MoretzCarrie Fuller
Emily ProcterLeah Fuller
Nia LongSherri
Lisa ArrindellDanielle- Bryan James KittoTrent's Friend
- Luke RamseyFBI Agent #1
- Lonnie LamontFBI Agent #2
Marcus Lyle BrownErskine- Mehera BlumFuller's Secretary, Lucy
Shanna MoaklerPetra
Yuji OkumotoParsons
Yvonne LandryIsabella
Wendy BraunCoach Bonnie
Ann MahoneyCoach Lisa
Deneen TylerTassie
Max Van VilleChad
Sean LampkinCabbie
William RagsdaleBob
Kelly DowdleSurf Shop Girl
Jessica WhiteBra Model
Amy MorrisSpa Susan
Michelle ParylakSpa Joanne
Deena DillSpa Crystal- Paige ButcherBackground Model
- Lucy WolvertBackground Model
Tim SoergelSpeedo Guy- Jessica AndersonBikini Girl
- Breanna StartzelGirl in Bikini
- Preston ShoresAndrew
- Trevor ShoresAndrew
Sarah Joy BrownConstance
Adrian StatonSandy (sem créditos)