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Kyle MasseyCalvin Wheeler
Kay PanabakerEmily Watson
Mitchel MussoRaymond Figg
Carter JenkinsPreston Price
Mark Christopher LawrenceCalvin's Dad
Alesandra DurhamKate
Judith MorelandCalvin's Mom- Ibrahim Abdel-BaaithRondel
Yolanda StangeRondel's Mother- Sierra SquiresYoung Girl
- Ben HammondBoy
- Cameron JonesDishwasher
Cory McMillanA.C. Officer #1- Magarin Lee HobsonLeonard
- Emmit CannonThrash
- Eric DengMiles
- Kelly CoombsJulie
- Sean SekinoSimon
Dan LarsenMr. Dudley- Kelly StevensBilly
- Janice KnickrehmSchool Librarian
Joel BishopChuck
Heather BeersHolly- Reb FlemingDog Show Official
- Teri CowanHead Judge
- Jansen DavisOlder Reporter
- Kelly ChapmanYoung Reporter
- Michael Todd BehrensFather
Chester the ChihuahuaChester (sem créditos)