Geração Prozac
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Christina RicciElizabeth Wurtzel
Jason BiggsRafe
Anne HecheDr. Sterling
Michelle WilliamsRuby
Jonathan Rhys MeyersNoah
Jessica LangeMrs. Wurtzel
Lou ReedLou Reed
Jesse MossSam
Nicholas CampbellDonald- Zoe MillerElizabeth at 12
Sheila PatersonGrandmother
Rob FreemanMister Cool- Nicole ParkerWaitress
Frida BetraniJulia- Klodyne RodneyNurse
Ian TraceyRolling Stone Editor- Wendy NoelMrs. Edelman
Bill MarchantLecturer- Tom KentLecturer
- Christine AntonMrs. Stevenson
Cindy LentolSheryl
Paula PlumGeeky Mom- Paul HooverGeeky Dad
- Tammy BentzAnnouncer
Emily PerkinsEllen- Maddy CapozziAmy
Claude de MartinoGrandfather- Charles AndreMugger
Mike MitchellPurse Snatcher
Brad SwaileStudent
Charles SiegelDr. Isaacs
Charles SinghKhalil
Chiara ZanniRuby's Roommate- Stephen BasiloneWarren
Devon DiepStudent (sem créditos)- Jack FleischerHarvard Student (sem créditos)
- Colby JohannsonFrat Guy (sem créditos)
Alma MartinezProfessor (sem créditos)- Josh MeadFrat Guy (sem créditos)
- Todd PoudrierLaw Student (sem créditos)
- Jennifer RappoStudent (sem créditos)
- Ron TruppaHarvard Undergrad (sem créditos)
- Andrew WashingtonStudent (sem créditos)