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Adam SandlerGeorge Simmons
Seth RogenIra Wright
Leslie MannLaura
Eric BanaClarke
Jonah HillLeo Koenig
Jason SchwartzmanMark Taylor Jackson
Aubrey PlazaDaisy Danby
RZAChuck
Aziz AnsariRandy
Maude ApatowMable
Iris ApatowIngrid
Torsten VogesDr. Lars
Allan WassermanDr. Stevens
Rod ManRod Man
Wayne FedermanComedy & Magic Manager
Mike O'ConnellMySpace Escort
James TaylorJames Taylor
Nicole ParkerDawn
Nydia McFaddenMandy
Andy DickAndy Dick
Charles FleischerCharles Fleischer
Nicol PaoneGeorge's Sister
George CoeGeorge's Dad
Budd FriedmanBudd Friedman
Monty HoffmanMonty Hoffman
Carol LeiferCarol Leifer
Paul ReiserPaul Reiser
Mark SchiffMark Schiff
George WallaceGeorge Wallace
Norm MacdonaldNorm Macdonald
Dave AttellDave Attell
Sarah SilvermanSarah Silverman
Bryan BattGeorge's Agent
Maggie SiffRachel
EminemEminem
Ray RomanoRay Romano
Jon BrionJon Brion- Sebastian SteinbergSebastian Steinberg
James GadsonJames Gadson- Arshad AslamYo Teach Cast Member
Bo BurnhamYo Teach Cast Member
Miki IshikawaYo Teach Cast Member
Kenny Copeland Jr.Yo Teach Cast Member
Calvin SykesYo Teach Cast Member
Ca'Shawn SimsYo Teach Cast Member- Mandi KreisherYo Teach Cast Member
Phillip Andre BotelloYo Teach Cast Member
Carla GalloMiss Pruitt on Yo Teach
Ernest Lee ThomasYo Teach Principal
Tonita CastroBonita- Carlos AndradeGardener
Steve BannosDeli Manager
Justin LongRe-Do Guy
Lucas AstromCollege Guy with Camera
Tyler SpindelCollege Guy with Camera- Deamor Yi8-Year-Old Girl Fan
Elaine KaoMom with Camera
King KedarFamily with Camera- Andre Butler Jr.Family with Camera
Tanya AckerFamily with Camera
Jarrett GrodeMagician
Qiana ChaseChuck's Wife- Tom AndersonTom Anderson
John HartmannPrivate Jet Pilot
Dave RathSan Francisco Theatre Manager
Dan HarmonPaparazzi at Medical Center- Brandon CournoyerPaparazzi at Medical Center
Kyle KinanePaparazzi at Medical Center
Mark CohenEmcee at Improv- Denise MeyersonDeli Customer
Joanie MarxDeli Customer
Adam J. BernsteinHot Dog-Eating Champion's Son
Da'Vone McDonaldHot Dog-Eating Co-Star
Orny AdamsOrny Adams
Al LubelAl Lubel
Jerry MinorJerry Minor
Eleanor ZeeGeorge's Mom
Ben MeyersonGeorge's Brother-In-Law
Sammy JackGeorge's Young Nephew- Kim TaylorKim Taylor
Andrea ZonnAndrea Zonn
Kate MarkowitzKate Markowitz
Arnold McCullerArnold McCuller- Larry GoldingsLarry Goldings
Luis ConteLuis Conte
Russ KunkelRuss Kunkel- Brad GrunbergComedy & Magic Club Audience
Brian LallyComedy & Magic Club Audience
Jimmy JohnsonJimmy Johnson
Janeane GarofaloFriend in video (imagens de arquivo) (sem créditos)
Ben StillerFriend in video (imagens de arquivo) (sem créditos)
Judd ApatowFriend in video (voz) (imagens de arquivo) (sem créditos)