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Steve CarellDavid Sheff
Timothée ChalametNic Sheff
Maura TierneyKaren Barbour
Amy RyanVicki Sheff
Christian ConveryJasper Sheff
Oakley BullDaisy Sheff
Kaitlyn DeverLauren
Stefanie ScottJulia
Julian WorksGack
Jack Dylan Grazer12-Year-Old Nic Sheff
Zachary Rifkin8-Year-Old Nic Sheff
Kue Lawrence5-Year-Old Nic Sheff
Timothy HuttonDr. Brown
Amy ForsythDiane
Andre RoyoSpencer
Ricky LowDestiny
LisaGay HamiltonRose
Carlton WilbornVince
Amy AquinoAnnie Goldblum
Marypat FarrellJulia's Mother
Brandon James CienfuegosKid
Cheska CoronaKid
Mandeiya FloryKid
Martha T. NewmanFlight Attendant
Minerva GarcíaNurse @ Bellevue
Nikki SnipperAirline Attendant
Anastasia LeddickSpeaker @ 12 Step Meeting
Edward FletcherMinister
Justin Townes EarleWedding Guest
Seann GallagherFather @ Graduation
Brooklin ThacherPrincipal @ Graduation
Sasha Kelly JacksonEMT
Tom BeyerMeeting Leader
David MendenhallRocker (sem créditos)