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Leonardo DiCaprioDr. Randall Mindy
Jennifer LawrenceKate Dibiasky
Meryl StreepPresident Orlean
Cate BlanchettBrie Evantee
Rob MorganDr. Teddy Oglethorpe
Jonah HillJason Orlean
Mark RylancePeter Isherwell
Tyler PerryJack Bremmer
Timothée ChalametYule
Ron PerlmanBenedict Drask
Ariana GrandeRiley Bina
Kid CudiDJ Chello
Himesh PatelPhillip
Melanie LynskeyJune Mindy
Michael ChiklisDan Pawketty
Tomer SisleyAdul Grelio
Paul GuilfoyleGeneral Themes
Robert JoyCongressman Tenant
Jack AlbertsOliver- TingWin
Lance A. WilliamsDaniel
Shimali de SilvaNisha
Hettienne ParkDr. Calder
Rafael SilvaNasa Scientist
Lonnie FarmerOld Aide #1- Homa Sarabi-DaunisWhite House Office Worker
- Barbara DouglassOffice Worker
Rena MaliszewskiAnchor Reporting On Colon
Erik ParilloSherriff Conlon- Robert Hurst RadochiaEvan Mindy
Conor SweeneyMarshall Mindy
Ross PartridgeKeith Ollens- Richard DonellyOld Aide #2
Liev SchreiberBash Narrator (voz)
Samsara YettIsherwell Child Aide
Meara Mahoney GrossIsherwell Child Aide- Jaden OnwuakorIsherwell Child Aide
Staci RobertsLinda Dicalio- Wendy BellevueIsherwell Child Handler
- Mishka YarovoyExecutive
Chris EverettChief Editor Paula Woods
Annette MillerMrs. Tanken
Stephen ThorneBenjamin- Aimee DohertyPasserby
Natalie RebenkoffTalent PA
Gary TanguayNews Anchor #2
Georgia LymanGroomer Thalia- Patricia DeHaneyHair Person
Ben SidellStage Manager
Therese PlaehnAutopsy Editor In Charge
Omar GhonimDamian- Jody O'NeilStage Manager #2
Meghan LeathersMedia Quant
Ashleigh BanfieldDalia Hensfield
Sarah SilvermanSarah Benterman
Richard SneeSenator Lerner- Darryl WootenFBI Agent
- Danielle WaxmanCollege Girl
- Jeffrey SmithBlind Man FBI Agent
Jon GlaserMeow Man
Dorothy DwyerOld Tough Lady- Odis SpencerChief Justice
- Sarah NolenSammy Puppeteer
Alvin KeithHarrison Telms- Alaina PintoAmerican Reporter
Lizzie ShortFrench Reporter- Juri LoveJapanese Reporter
Sujoy DeHindi Reporter- Brahms GuignardHaitian Reporter
- Sergei BushmanovRussian Reporter
Lewis D. WheelerMission Coordinator
Steve GagliastroOnlooker
David J. CurtisGuy
Kevin Craig WestSecretary of State- Alison WellerSecretary of Education
Rob LévesqueSecretary of Interior- Sam ZephirCaptain
Dee NelsonDr. Lisa Inez- Beau AllenDr. Talcamont
Rebecca GibelWaitress
Brian FahertyGuy from the Bar
Celeste OlivaNearby Diner- Amanda CassRioting Patron
Roman MitichyanRioting Patron- Paul MariniRioting Patron
Alex HuynhRioting Patron
Michael JibrinFederal Agent
Bill MootosFederal Attorney
Patti TippoFrench President- Allyn BurrowsMr. Dibiasky
- Tori Davis LawlorMrs. Dibiasky
- Joy LangHousewife
- June HolmesGirl in Commercial
- Graham HolmesBoy in Commercial
- Jacob SanditenYule's Friend
- Anthony MarreseOther Friend
Caroline BergwallTeen Girl Friend- Anania WilliamsShort Guy Friend
Nate RichmanStocky FBI Agent
Wes JohnsonDon't Look Up'er
John BucyDon't Look Up'er- Patrick GoverDon't Look Up'er
- Conrad PerryDon't Look Up'er
- Matt RouillardDon't Look Up'er
- Christopher DeschenesDon't Look Up'er
Patrick Michael StrangeJust Look Up'er- J.P. AaronJust Look Up'er
- Daniela AugustJust Look Up'er
- Nicholai SenatPuppet Show Kid
- Alexandra ZilchPuppet Show Kid
- Jonathan KobsTruthslinger303
Bianca de la GarzaEntertainment Journalist- Caitlin IshibashiDJ at Concert
- Claire DavisBass Player
- Elder Isaiah PerezOrgan Player
- Coran Spardakis HenleyDrummer
Lance NorrisLoyal Supporter- Ralph M. StudleyKid Rock Body Double
Frank RidleyFlight Director- Andrew HaserlatMission Tech
- Jayne McLendonCommand Tech
Ishaan KhatterRaghav Manavalan- Khaldoun RajehEgyptian Family
- Sheren RajehEgyptian Family
- Khaled RajehEgyptian Family
- Kareem RajehEgyptian Family
- Ahmad RajehEgyptian Family
- Adila RajehEgyptian Family
- J.T. TurnerOld Billionaire
- Ed PeedLobbyist
Zach Holmes#LaunchChallenge MeTuber (sem créditos)
Chris EvansDevin Peters (sem créditos)
Marissa CarpioReporter with Big Hair (sem créditos)
Luan GallagherBoy Looking at the Meteor