O Colecionador de Ossos
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Denzel WashingtonLincoln Rhyme
Angelina JolieAmelia Donaghy
Queen LatifahThelma
Michael RookerCaptain Howard Cheney
Michael McGloneDetective Kenny Solomon
Luis GuzmánEddie Ortiz
Leland OrserRichard Thompson
John Benjamin HickeyDr. Barry Lehman
Bobby CannavaleSteve, Amelia's Boyfriend
Ed O'NeillDetective Paulie Sellitto
Richard ZemanLieutenant Carl Hanson
Olivia BirkelundLindsay Rubin
Gary SwansonAlan Rubin- James BulleitTrain Engineer
Frank FontaineGrandfather
Zena GreyGranddaughter
Daniel BrochuNYU Student
Desmond CampbellTaxi Inspector- Christian VelizYoung Boy
- Mercedes GómezOrtiz's Mother
- Mary C. HammettGirlfriend in Nightclub
- Amanda GayGirl in Nightclub
Steve AdamsGas Worker
Larry DayGas Worker- Burke LawrencePolice Instructor
Terry SimpsonCop in Apartment
Eric DavisCop in Apartment
Arthur HoldenBookstore Clerk
Yahsmin DaviaultRhyme's Sister- Keenan MacWilliamRhyme's Niece
David WarshofskyAmelia's Partner
Mateo GómezHot Dog Vendor
Ted WhittallOrtiz's Assistant
Peter Michael DillonHomicide Detective- Jonathan StarkMale Detective
Fulvio CecereForensics Expert- Hal ShermanFingerprint Cop
Russell YuenForensics Worker- Andy BradshawUniform Cop
- Jean-Marc BissonRescue Worker
- Christopher BregmanRescue Worker
- Sonya BiddleNurse
Phillip NoyceCustomer in Antique Bookshop (sem créditos)- Charles AlonsoNews Reporter (sem créditos)
Michael ArthurNYPD Officer (sem créditos)
Alex LorreRescue Worker (sem créditos)
Todo SegallaCop (sem créditos)- Andrew SemplePerp (sem créditos)