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John TravoltaJames
Kirstie AlleyMollie
Olympia DukakisRosie
George SegalAlbert
Abe VigodaGrandpa
Bruce WillisMikey (voz)
Twink CaplanRona- Jason SchallerMikey
- Jaryd WaterhouseMikey
- Jacob HainesMikey
- Christopher AydonMikey
Joy BoushelMelissa
Don S. DavisDr. Fleischer- Louis HeckerlingLou
Brenda CrichlowSecretary- Andrea MannSalesgirl
- Douglas TuckCab Stealer
Alex BruhanskiStreet Worker- Casey GrantAdmitting Clerk
- Oscar B. RamosHospital Worker
Aurelio DinunzioOrderly- Jeff IrvineAdmitting Doctor
- Shirley BarclayNurse
William B. DavisDrug Doctor- David BernerMr. Impatience
Jerry WassermanMr. Anal- Daliah NovakCarrie
- Zena DarawallaLupe
- Nicholas RiceHarry
Neal IsraelMr. Ross
Blu MankumaDirector- William BritosHome Orderly
Dee Jay JacksonBurly Orderly- Ida BernerLady
- Bea CartmellLady
- Eleanor MainesLady
Mollie HeckerlingLittle Girl- Ryan McIntoshLittle Boy
Gerry BeanPilot Friend
Deryl HayesPilot Friend
Enid SaundersEster- Nicole StevensSilly Baby
- Christy SmithBaby Megan
- Sabrina BaileySand Box Baby
- Farah AbassiChatting Baby
- Amber BrownmillerBlowing Kiss Baby
- Ariel PerrymanNursery Baby
- Nigel John CroweNursery Baby
- Michael Joseph MateriNursery Baby
Joan RiversJulie (voz) (sem créditos)- Aaron JeffordFireman (sem créditos)