Como Cães e Gatos
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Jeff GoldblumProfessor Brody
Elizabeth PerkinsMrs. Brody
Alexander PollockScotty Brody
Miriam MargolyesSophie the Castle Maid
Tobey MaguireLou the Beagle (voz)
Alec BaldwinButch (voz)
Sean HayesMr. Tinkles (voz)
Susan SarandonIvy (voz)
Joe PantolianoPeek (voz)
Michael Clarke DuncanSam (voz)
Jon LovitzCalico (voz)
Charlton HestonThe Mastiff (voz)
Glenn FicarraRussian Blue (voz)
Billy WestNinja Cat (voz)
John Michael HigginsGinger Kitten (voz)
Richard Steven HorvitzPuppy in Barn (voz)
Frank WelkerBuddy (voz)
Frank C. TurnerThe Farmer
Lauren K. RobekPie Mom (as Kirsten Robek)
Mar AndersonsGuard at Gate
Gillian BarberFactory Receptionist
Carol Ann SusiSophie's Sister- Randi KaplanSophie's Sister
- Mary BogueSophie's Sister
Alvin SandersMason Employee
Mark SchooleyMason Employee
Lou BolloWorker
Scott NicholsonWorker- Trish SchillWorker
- Babe DolanWife Passenger
- Reg GlassTruck Driver (as Reginald Glass)
- Charles AndreTruck Driver
Peggy LoganNurse- Alicia MichelleJogger
Pamela PerryYorkie Dog Owner- Victor WilsonDoberman Drill Sergeant (voz)
Salome JensCollie at HQ (voz)
Danny MannNinja Cat (voz)
Paul PapeWolf Blitzer (voz)
Myron NatwickMr. Mason
Doris ChillcottMrs. Calvert